Endocrine Abstracts

To better understand the molecular and cellular nature of paediatric combined pituitary hormone deficiency diseases, our laboratory has recently generated a novel mouse model of the severe paediatric diseases caused by mutations in the LHX3 transcription factor gene. Through gene targeting, we have produced an Lhx3 W227Ter mouse modeling the LHX3 W224Ter (loss of carboxyl terminus) human disease. Patients with the W224Ter mutation are of short stature and ...

Our goal is to better understand the molecular and cellular nature of paediatric combined pituitary hormone deficiency diseases in order to facilitate improved diagnosis, treatment, and family counselling. LIM-homeodomain transcription factors regulate many aspects of development and mutations in the genes that encode these regulatory proteins are associated with several diseases. The LHX3 LIM-homeodomain protein is critical for pituitary gland organogenesis and some nervous s...

Childhood obesity is a serious public health challenge. Bariatric surgery is gaining popularity as a treatment modality for severely obese adolescents.Backgrounds: To report the safety and 1 year outcome data on morbidly obese adolescents that underwent bariatric surgery at a tertiary hospital in the UK.Methods: A retrospective review of patients (mean preoperative BMI 50.4 kg/m2; mean BMI SDS +4.2) who underwent bariatr...